Only two female condoms — the FC1 female condom and its replacement, the FC2 female condom — have Food and Drug Administration approval in the U.S. The FC1 female condom, which is made of plastic (polyurethane), is no longer being produced. The FC2 female condom is made of synthetic latex — safe for those with allergies to natural rubber latex — and is pre-lubricated with a silicone-based lubricant.