Sonora Quest is implementing an immunoassay such as the enzyme-linked immunosorbent assay (ELISA). We perform our own validation using stringent acceptability criteria for precision, reproducibility, accuracy, method comparison, cross-reactivity, and clinical performance before starting patient testing. The accuracy of Sonora Quest’s SARS-CoV-2 serology testing performance characteristics is on par with other common virology antibody tests routinely performed at Sonora Quest (eg, Measles, Mumps, Rubella).